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2008 Nov;28(11):738-43

The study enrolled 18 individuals diagnosed with PD and cognitive symptoms consistent with mild cognitive impairment

Urea assay kit (ab83362) and Human alpha 1 Antitrypsin ELISA Kit (ab108799) were from Abcam (Cambridge, MA)

While glutathione itself is included in this formula, much of the clinical research has focused on its precursor, NAC (N-acetylcysteine), which helps replenish glutathione levels

Mechanistically, detoxification of peroxides by mammalian GPx-1 proceeds by way of a bi-substrate ping-pong-type enzymatic mechanism in which saturation kinetics are not observed